PROGRAM

Monday, February 11, 2008
  8:00  - 18:00 Registration, Lobby of the Auditorium Maximum
  8:30  -   9:00

Opening Remarks by Horst Domdey, Scientific Director of BayGene
State Minister Dr. Thomas Goppel, Bavarian State Ministry for Sience, Research and the  Arts (requested)
Wolfgang A. Herrmann, President Technical University Munich (requested)

Signaling Pathways / Chairs: Lukas Huber & Eugen Kerkhoff
  9:00  -   9:35 Mapping Signal Transduction Pathways by Proteomics
Walter Kolch
Beatson Institute for Cancer Research, Glasgow, Scotland
  9:35  - 10:10

Spatiotemporal Regulation of EGFR/MAP Kinase Signaling
Lukas Huber 
Biocenter, Division of Cell Biology, Medical University Innsbruck, Austria  

10:10 - 10:45 Targeting Ubiquitin Signaling in Cancer
Ivan Dikic
Institute of Biochemistry, Goethe University Medical School, Frankfurt am Main, Germany
10:45 - 11:15 Coffee Break - Visit also the Exhibition and Posters
11:15 - 11:50 Towards an Understanding of BRAF Signaling in Melanoma
Richard Marais
The Institute of Cancer Research, London, UK
11:50 - 12:25 The RNAi Strategy in Cancer: Towards the Achilles Heal of Cancer
Roderick L. Beijersbergen
he Netherlands Cancer Institute Division of Molecular Carcinogenesis Amsterdam, The Netherlands
12:25 - 13:00 Challenges and Applications of High-Throughput RNA Interference Screens
Bernard Mathey-Prevot
Drosophila RNAi Screening Center, Dept. of Genetics, Harvard Medical School Boston, MA, USA
13:00 - 14:00 Lunch Break
Cancer Research in Bavaria / Chair: Horst Domdey
14:00 - 14:30 OncoGenome Analysis as Basis for Cancer Target Identification and Development
of Novel Therapies
Axel Ullrich
Max-Planck-Institute of Biochemistry, Martinsried, Germany
14:30 - 15:00 Chromosomal Instability through Wnt Signaling
Juergen Behrens
Nikolaus-Fiebiger-Center of Molecular Medicine
University of Erlangen, Germany
15:00 - 15:30 A New Strategy for Searching Biomarkers in Plasma Using Biobanks and
Quantitative Proteomics
Friedrich Lottspeich
Max-Planck-Institute of Biochemistry, Martinsried, Germany
15:30 - 16:00 Molecular Mechanisms of Melanoma Development
Anja Bosserhoff
Institute of Pathology University of Regensburg, Germany
16:00 - 16:30 Coffee Break - Visit also the Exhibition and Posters
Molecular Imaging / Chairs: Hans-Jürgen Wester & Andreas Jacobs
16:30 - 17:05 Molecular Imaging in NeuroOncology
Andreas H. Jacobs
Department of Neurology, Klinikum Fulda, and Laboratory for Gene Therapy and Molecular Imaging MPI for Neurological Research, Cologne, Germany
17:05 - 17:45 Molecular and Functional Imaging of Cancer
Kristine Glunde
Radiology Department - NMR Research - Oncology Section Johns Hopkins University School of Medicine, Baltimore, MD, USA
Bioinformatics / Chairs: Rainer Spang & Jürgen Haas
17:45 - 18:20 Alternative Splicing in Tumors: Detection and Interpretation
Terry Speed
Department of Statistics and Program in Biostatistics University of California, Berkeley, CA, USA
18:20 - 18:40 A Bioinformatics Approach to the Molecular Systematics of Lymphoma
Stefan Bentink
Institute of Functional Genomics Division of Bioinformatics University of Regensburg, Germany
18:40 - 19:15 Integrated Bioinformatics for Deciphering Complex Pathomechanisms in Cancer
Roland Eils
Theoretical Bioinformatics Department German Cancer Research Center Heidelberg, Germany
20:00 Get together and dinner at the Pinakothek der Moderne
Tuesday, February 12, 2008
  8:00  - 18:00 Registration, Lobby of the Auditorium Maximum
Cancer Stem Cells / Chairs: Christoph Klein & William Thilly
8:30  -  9:05 Wnt Signaling Modulates Intestinal and Mammary Cancer
Stemness and Malignant Behavior
Riccardo Fodde
Department of Pathology, Josephine Nefkens Institute Erasmus University, Rotterdam, The Netherlands
 9:05  -   9:40 Therapeutic and Prognostic Potential Role of Cancer Stem Cells
Ruggero De Maria
Istituto Superiore di Sanità Rome, Italy
 9:40  - 10:15 The Role of HER2 and PTEN in Normal and Malignant Stem Cell Self-Renewal and
the Herceptin Resistance
Hasan Korkaya
University of Michigan Comprehensive Cancer Center Ann Arbor, MI, USA
10:15 - 10:50 Do Malignant Peripheral Nerve Sheath Tumors Arise from Endogenous Stem Cells?
Jack T. Mosher
Center for Stem Cell Biology HHMI / University of Michigan, Ann Arbor, MI, USA
10:50 - 11:15 Coffee Break - Visit also the Exhibition and Posters
Advances in Cancer Therapy I / Chairs: Christian Brandts & Michael Detmar
11:15 - 11:50 Novel Molecular Targets in Acute Myeloid Leukemia
Christian Brandts
Dept. of Medicine, Hematology / Oncology University of Frankfurt, Frankfurt, Germany
11:50 - 12:25 Cellular Senescence in Lymphoma Development and Therapy
Clemens A. Schmitt
Hematology, Oncology, and Tumor Immunology Charité - Universitätsmedizin Berlin (CVK), and Max-Delbrück-Center for Molecular Medicine Berlin, Germany
12:25 - 12:55 Rapid high-resolution karyotyping by combining genome-wide SNP-mapping with exon expression arrays: An applied systems biology approach for cancer research
Dr. Matthias Prucha, Senior Application Specialist Affymetrix
(Sponsor of the Lunch Break)
12:55 - 14:00 Lunch Break
Clinical Oncology in Bavaria/ Chairs: Axel Ullrich
14:00 - 14:30 Therapeutic Antibodies in Oncology - Epitopes and Functions Discovery Oncology
Dr. Hans-Joachim Müller
Roche Penzberg, Germany
14:30 - 15:00 mTOR as a Promising Target for Cancer Therapy
Edward K. Geissler
Department of Surgery University of Regensburg, Regensburg, Germany
15:00 - 15:30 Molecular Definition of the Therapeutic Action of the Multi-Targeted Drug
SUTENT/ Sunitinib
Michaela Bairlein
Max Planck Institute of Biochemistry Martinsried, Germany
15:30 - 16:00 Coffee Break - Visit also the Exhibition and Posters
Tumor Metabolism & Immune Escape / Chairs: Falk Nimmerjahn & Marina Kreutz
16:00 - 16:35 Warburg Revisited: The Role of Glucose Metabolism in Cancer Immunology
Marina Kreutz
Experimental Hematology and Oncology, University of Regensburg, Germany
16:35 - 17:10 A Pivotal Role for p53: Balancing Aerobic Respiration and Glycolysis
Paul M. Hwang
National Heart, Lung, and Blood Institute, Cardiology Branch Bethesda, MD, USA
17:10 - 17:45 Metabolic Restraint of T Lymphocyte Activation and Migration
by Tumor-Conditioned Myeloid Cells
Vincenzo Bronte
Istituto Oncologico Veneto, Padova, Italy
17:45 - 18:20 TNF-Induced Tumor Ganglioside Synthesis as a Mechanism of Immune Evasion by Tumors
Charles Tannenbaum
Lerner Research Institute Department of Immunology, Cleveland, OH, USA
18:20 - 18:55 Genetic Regulation and Therapeutic Correction of Immune Escape in Cancer
George C. Prendergast
Lankenau Institute for Medical Research, Wynnewood, PA, USA
18:55 - 19:30 Immune Contexture and Clinical Outcome in Colorectal Cancer
Jerome Galon
Inserm U872, Cordeliers Research Center, Paris, France
20:00 Bavarian Dinner
Wednesday, February 13, 2008
 8:00  - 12:00 Registration, Lobby of the Auditorium Maximum
Cancer Genetics & Epidemiology / Chairs: Ute Felbor & Ulrike Peters
 8:30  -  9:05 Integrated Biological and Epidemiological Models of Carcinogenesis
William G. Thilly
Massachusetts Institute of Technology, Cambridge, MA, USA
 9:05  -  9:25 Transcriptional Profiling of Single Disseminated Breast Cancer Cells
Claudia Hartmann
Department of Oncogenomics University of Regensburg, Regensburg, Germany
 9:25  - 10:00 Modeling and Mining Cancer Genomes
Zhihu Ding
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
10:00 - 10:20 Genetic Characterization of Metastatic Precursor Cells in Prostate Cancer
Bernhard Polzer
Department of Oncogenomics University of Regensburg, Regensburg, Germany
10:20 - 10:45 Coffee Break - Visit also the Exhibition and Posters
10:45 - 11:20 Genetic Susceptibility to Colorectal Cancer
Richard S Houlston
Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
11:20 - 11:40 The ATM Gene in Familial Breast Cancer
Anne Hartmann
Institute of Functional Genomics University of Regensburg, Germany
11:40 - 12:15 Genetic Epidemiology of Colorectal and Prostate Cancer -
From Candidate Pathways towards a Genome-Wide Approach
Ulrike Peters
Fred Hutchinson Cancer Research Center, Seattle, WA, USA
12:15 - 13:30 Lunch Break
Advances in Cancer Therapy II / Chairs: Anja Muntau & Clemens A. Schmitt
13:30 - 14:05 Tumor and Lymph Node Lymphangiogenesis: Impact onCancer Metastasis
Michael Detmar
Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland
14:05 - 14:40 Tumor Antigens and Preclinical Models for Cancer Immunotherapy
Benoit Van den Eynde
Ludwig Institute for Cancer Research, Brussels, Belgium
14:40 - 15:15 Novel Molecular Defects in Acute Lymphoblastic Leukemia
Jan Cools
VIB Department of Molecular and Developmental Genetics, Katholieke Universiteit Leuven, Belgium
15:15 - 15:50 A Genomic Strategy to Personalize Breast Cancer Therapy
Anil Potti
Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA
15:50 - 16:00 Closing Remarks by Peter Oefner

BayGene Conference on

INTEGRATIVE CANCER GENOMICS

Session A: Signaling Pathways
Walter Kolch ACCEPTED
Beatson Institute for Cancer Research
Glasgow, UK
Email: wkolch@beatson.gla.ac.uk

Lukas Huber, MD ACCEPTED
Biocenter, Division of Cell Biology
Innsbruck Medical University
Austria
E-mail: Lukas.A.Huber@i-med.ac.at

Ivan Dikic, MD, PhD ACCEPTED
Institute of Biochemistry II
Goethe University Medical School
Frankfrut am Main, Germany
E-mail: Ivan.Dikic@biochem2.de

Richard Marais, PhD ACCEPTED
The Institute of Cancer Research
London
Email: richard.marais@icr.ac.uk

Roderick L. Beijersbergen, PhD ACCEPTED
The Netherlands Cancer Institute
Amsterdam, The Netherlands
Email r.beijersbergen@nki.nl

Bernard Mathey-Prevot, Ph.D. ACCEPTED
Drosophila RNAi Screening Center
Harvard Medical School
Boston, USA
Email: bprevot@receptor.med.harvard.edu

Session B: Cancer Research in Bavaria
Prof. Dr. rer. nat. Axel Ullrich ACCEPTED
Max Planck Institute of Biochemistry
Martinsried, Germany
E-mail: ullrich@biochem.mpg.de

Prof. Dr. Juergen Behrens ACCEPTED
Nikolaus-Fiebiger-Center of Molecular Medicine
University Erlangen
Erlangen, Germany
E-mail jbehrens@molmed.uni-erlangen.de

Dr. Friedrich Lottspeich ACCEPTED
Max Planck Institute of Biochemistry
Martinsried, Germany
E-mail: lottspei@biochem.mpg.de

Prof. Dr. Anja Katrin Bosserhoff ACCEPTED
Universität Regensburg
Institut für Pathologie
Molekulare Pathologie
Regensburg, Germany
Email: anja.bosserhoff@klinik.uni-regensburg.de

Session C: Molecular Imaging
Prof. Dr. Andreas H. Jacobs, MD ACCEPTED
Department of Neurology
Klinikum Fulda gAG, Germany and
Laboratory for Gene Therapy and Molecular Imaging
MPI for Neurological Research, Cologne
Email: andreas@nf.mpg.de

Kristine Glunde, Ph.D. ACCEPTED
Johns Hopkins University School of Medicine
Baltimore, USA
e-mail: kglunde@mri.jhu.edu

Session D:  Bioinformatics
Prof. Terry Speed ACCEPTED
University of California at Berkeley
Berkeley, USA
email: terry@stat.berkeley.edu

Stefan Bentink ACCEPTED
Institute of Functional Genomics
University of Regensburg
Regensburg, Germany
Email: Stefan.Bentink@klinik.uni-regensburg.de

Prof. Roland Eils ACCEPTED
Theoretical Bioinformatics Department
German Cancer Research Center
Heidelberg, Germany
Roland Eils: R.Eils@dkfz.de

BayGene Conference on

INTEGRATIVE CANCER GENOMICS

Session E: Cancer Stem Cells

Riccardo Fodde ACCEPTED
Dept. of Pathology,
Josephine Nefkens Institute,
Erasmus University Medical Center,
Rotterdam, The Netherlands
Email: r.fodde@erasmusmc.nl

Ruggero De Maria ACCEPTED
Istituto Superiore di Sanità
Roma, Italy
Email: rdemaria@tin.it

Hasan Korkaya, Ph.D.  ACCEPTED
Int Med-Hematology/Oncology
University of Michigan
Ann Arbor,USA
Email: hkorkaya@med.umich.edu

Jack T. Mosher, Ph.D. ACCEPTED
Center for Stem Cell Biology
University of Michigan
Ann Arbor, USA
Email: mosherjt@umich.edu

Session F: Advances in Tumor
Therapy I
Prof. Christian Brandts ACCEPTED
Dept. of Medicine, Hematology / Oncology
University of Muenster
Muenster, Germany
Email: cbrandts@uni-muenster.de

Prof. Dr. Clemens A. Schmitt, M.D. ACCEPTED
Hematology, Oncology, and Tumor Immunology
Charité - Universitätsmedizin Berlin (CVK), and
Max-Delbrück-Center for Molecular Medicine
Berlin, Germany
E-mail: clemens.schmitt@charite.de

Session G: Clinical Oncology in Bavaria
Dr. Hans Joachim Müller ACCEPTED
Disxovery Onkologie
Roche Penzberg, Germany

Edward K. Geissler, PhD ACCEPTED
University of Regensburg
Department of Surgery
Regensburg, Germany
e-mail: edward.geissler@klinik.uni-regensburg.de

Michaela Bairlein ACCEPTED
Max Planck Institute of Biochemistry
Martinsried, Germany
E-mail: bairlein@biochem.mpg.de

Session H: Tumor Metabolism  &
Immue Escape
Prof. Dr. Marina Kreutz ACCEPTED
Universitätsklinik Regensburg
Experimentelle Hämatologie und Onkologie
Regensburg, Germany
Email: marina.kreutz@klinik.uni-regensburg.de

Paul M. Hwang, M.D., Ph.D. ACCEPTED
Cardiology Branch
Bethesda
Email: hwangp@mail.nih.gov

Vincenzo Bronte, MD ACCEPTED
Istituto Oncologico Veneto
Padova, Italy
Email: enzo.bronte@unipd.it

Charles Tannenbaum, PhD ACCEPTED
Lerner Research Institute
Department of Immunology
Cleveland Clinic Foundation
Cleveland, USA
Email: TANNENC@ccf.org

George C. Prendergast, PhD ACCEPTED
Lankenau Institute for Medical Research
Wynnewood, USA
Email: prendergast@limr.org

Jerome GALON, PhD ACCEPTED
Inserm U872, Cordeliers Research Center
Paris, France
Email: jerome.galon@crc.jussieu.fr

BayGene Conference on

INTEGRATIVE CANCER GENOMICS

Session I: Cacer Genetics &       Epidemiologie

Prof. William G. Thilly ACCEPTED
Massachusetts Institute of Technology
Cambridge, USA
Email: thilly@mit.edu

 Dr. Claudia Hartmann ACCEPTED
Institut für Pathologie
Klinikum der Universität Regensburg
Regensburg, Germany
Email: Claudia.hartmann@klinik.uni-regensburg.de

Dr. Bernhard Polzer ACCEPTED
Institut für Pathologie
Klinikum der Universität Regensburg
Regensburg, Germany
Email: bernhard.polzer@klinik.uni-regensburg.de

Richard S. Houlston ACCEPTED
Institute of Cancer Research
Surrey, UK
Email: Richard.Houlston@icr.ac.uk

Dr. Anne Hartmann ACCEPTED
Institute of Functional Genomics
University of Regensburg, Germany
Email: anne.hartmann@klinik.uni-regensburg.de

Ulrike Peters, Ph.D. ACCEPTED
Fred Hutchinson Cancer Research Center
Department of Epidemiology, University of Washington
Seattle, USA
Email: upeters@fhcrc.org

Session K: Advances in Cancer Therapy II
Michael Detmar, MD ACCEPTED
Institute of Pharmaceutical Sciences
Swiss Federal Institute of Technology (ETH) 
Zurich, Switzerland
Email: michael.detmar@pharma.ethz.ch

Benoi Van den Eynde, M.D., Ph. D. ACCEPTED
Ludwig Institute for Cancer Research
Brussels, Belgium
Email: vandeneynde@licr.ucl.ac.be

Jan Cools, PhD ACCEPTED
VIB Department of Molecular and Developmental
Genetics
Leuven, Belgium
E-mail: jan.cools@med.kuleuven.be

Anil Potti, MD ACCEPTED
Duke Institute for Genome Sciences and Policy
Division of Medical Oncology
Durham, UK
Email: anil.potti@duke.edu